In the mid-19th century, Dr. Gordon Ramsay is wrongfully convicted of murder and set to be executed. However, he is mysteriously saved by Dr. Joel Cadman, a surgeon with a peculiar interest in unorthodox medical practices. Dr. Cadman introduces Ramsay to an ancient Indian drug called "Nind Andhera," which induces a state of death-like sleep. After Ramsay successfully fakes his own death to escape execution, he joins Dr. Cadman's household and agrees to assist in his strange experiments, unaware of the full extent of Cadman's macabre ambitions.

Dr. Cadman's true goal is revealed to be the unlocking of the secrets of the human brain through radical surgery, using unsuspecting victims as subjects. Within the eerie confines of Cadman's mansion, Ramsay encounters a range of characters - from a helpful assistant named Udu to various unfortunate patients who have fallen prey to Cadman's ruthless quest for knowledge. As Ramsay delves deeper into these experiments, he begins to uncover the horrifying reality of Cadman's work and the twisted fate awaiting those involved in the doctor's dark pursuits. The stakes rise as questions of ethics and morality clash with scientific curiosity, leading Ramsay toward an inevitable confrontation with the dire consequences of their actions.