Four middle-aged friends, Doug, Woody, Bobby, and Dudley, are suburban men living unfulfilled lives in Cincinnati. Doug is a dentist with a teen son he hardly connects with, Woody is a wealthy but bankrupt trader, Bobby is a plumber oppressed by his overbearing wife, and Dudley is a clumsy computer programmer who fails at finding love. United by their love for motorcycle riding, they form a biker gang dubbed "Wild Hogs" to escape their mundane lives. In a bid to break away from their routine existence, they decide to embark on a cross-country motorcycle trip to the Pacific Coast. Their journey represents a desperate attempt for freedom and a break from their domestic woes.

As their road trip unfolds, the group encounters various misadventures that test their friendship and individual courage. The pivotal moment comes when they stumble upon the small town of Madrid, New Mexico, and inadvertently provoke a real biker gang, the Del Fuegos, led by the menacing Jack. This encounter challenges their suburban pretenses and forces them into situations that are far out of their comfort zones. The trip transforms into a quest for self-discovery and redemption, as the "Wild Hogs" navigate the dangers and comic mishaps on the road to finding what they truly seek from life.