A technician returns from the Arctic with a mysterious frozen specimen. Unbeknownst to him, this sample contains a dangerous entity, a gelatinous, flesh-eating creature thought to have been eradicated previously. In the blissful ignorance of a suburban setting, the peril sits forgotten within a container in the man’s home. His wife inadvertently releases the Blob when she tosses the container into the sink while defrosting the freezer, unleashing the growing menace into the sewer system. As the creature consumes everything in its path, increasing in size exponentially, it makes its way back to the surface, starting with small animals and escalating to unsuspecting residents of the quiet town.

With each victim, the townspeople's disbelief turns to terror, as they scramble to understand and contain the spread of the monstrous blob. A group of intrepid teenagers, witnessing the creature’s onslaught, attempt to warn the disbelieving adults and local authorities about the escalating danger. Meanwhile, the Blob begins to consume larger portions of the community, creeping into public spaces and even causing chaos at a bowling alley, leaving the town's very existence hanging in the balance. Hindered by skepticism and bureaucratic inertia, the young heroes find themselves leading the desperate fight for survival, racing against time to find a way to stop the Blob before it devours everything in sight.