In 2013, Los Angeles has become an island for the country's outcasts after an immense earthquake separates it from the mainland. Governed by a theocratic presidential regime, the United States enforces a strict moral code, exiling those who don't conform to the autonomous city of Los Angeles. Enter Snake Plissken, a cynical anti-hero and former war veteran who's no stranger to dangerous missions. After a mission gone awry, Snake is captured by the authorities and given an ultimatum by Commander Malloy and his subordinate, Brazen. Infected with a deadly toxin, Snake must enter the lawless, dystopian Los Angeles to retrieve a doomsday device stolen by the President's rebellious daughter, Utopia, who has allied herself with Cuervo Jones, a notorious leader of the Shining Path gang.

Maneuvering through the treacherous, gang-ruled streets of L.A., Snake enlists the help of various miscreants to achieve his mission, including a surfer named Pipeline, a tour guide named Map to the Stars Eddie, and Taslima, a woman striving to earn her way to the "free" lands. As the clock ticks on his life due to the injected toxin, he battles the anarchy surrounding him, using his cunning and combat skills to confront the eclectic and deadly assortment of inhabitants. Wrestling with his own survival and the high-stakes task of neutralizing the doomsday threat, Snake must decide where his loyalties truly lie in a cityscape stripped of order and filled with chaos.