A group of college students, including Cindy Campbell, Ray Wilkins, and Brenda Meeks, are brought together by their professor, Oldman, and his charming yet eccentric assistant, Dwight Hartman, to participate in a study on sleep disorders. Unbeknownst to the students, they are actually being lured into a haunted mansion named Hell House, under the guise of a scientific experiment. The mansion holds dark secrets and is plagued by malevolent spirits. Each character brings their own quirks and personality traits, adding to the comedic chaos that ensues as they confront the supernatural occurrences within the house.

As the students settle into Hell House, they start experiencing bizarre and frightening events, from possessed household items to eerie apparitions. The skeptical group quickly realizes that the hauntings are real and they must band together to survive. Along the way, they face numerous parodies of popular horror films, leading to hilariously absurd situations. In their quest to escape the horrors of Hell House, the group encounters various challenges that test their wits and sanity, leading to unexpected twists and comedic turns that keep them on their toes.