After adapting to the modern world following his reawakening, Steve Rogers, a super-soldier known as Captain America, continues his work with the espionage agency S.H.I.E.L.D. under the direction of Nick Fury. His struggle to assimilate into contemporary society is further complicated by the constant threat of international terrorism and internal deceit. On a mission aboard a S.H.I.E.L.D. vessel overtaken by pirates, Rogers discovers that fellow agent Natasha Romanoff has another agenda: to retrieve data from the ship's computers for Fury. The incident seeds doubt in Rogers about the integrity of his superiors and the transparency of the organization.

Rogers' skepticism is amplified when Fury is ambushed by mysterious assailants and warns Rogers to trust no one before seemingly succumbing to his injuries. This event propels Rogers into a complex web of intrigue that unravels the deeper corruption within his once-trusted agency. He finds an ally in Romanoff, and together they go on the run, attempting to evade the formidable forces sent to subdue them, including a formidable and enigmatic assassin known only as the Winter Soldier. His encounters with this new adversary challenge Rogers' combat prowess and commitment to his ideals, raising the stakes in his fight to uncover the truth and protect the world from looming threats.