In the early 1970s, in a small Pennsylvania town, a young 14-year-old girl named Susie Salmon takes a shortcut home from school through a cornfield. Tragically, she is lured into an underground den by a neighbor, George Harvey, a reclusive man who hides a dark secret. This encounter leads to Susie's untimely death, marking a heartbreaking loss for her family and throwing them into a tumultuous period of grief and quest for understanding. The tragedy shatters the family, with each member grappling with the loss in their unique ways, struggling to hold onto any sense of normalcy and justice in the wake of such a profound loss.

Susie finds herself trapped in a liminal space between life and the afterlife, a vibrant, shifting realm she refers to as her "In-Between." From this vantage point, she watches over her family and observes the investigation into her disappearance and presumed death. She experiences a range of emotions, from longing to be back with her family to a desire for revenge against her murderer. Meanwhile, her family's search for answers leads them on a difficult journey, uncovering uncomfortable truths and testing the bounds of their strength, love, and resilience. Through this process, they begin to unravel not only the mystery of Susie's fate but also the complex web of personal and communal connections that define their lives and relationships.