Ten strangers receive mysterious invitations to a secluded African safari lodge. Upon arrival, they discover they have been brought together under false pretenses by their unseen host, who accuses each guest of a grave crime. As the group grapples with their past misdeeds, a nursery rhyme detailing ten little Indians begins to eerily play out in their reality, predicting the deaths of each person one by one.

As paranoia and fear escalate, alliances form and dissolve while the remaining guests desperately try to identify the orchestrator of their grim fate. The lodge, cut off from any hope of rescue, becomes a claustrophobic arena of suspicion and imminent danger. With each death, the survivors grow more frantic, and the rhyme continues to ominously tick down. When the group's number dwindles further, it becomes apparent that everyone may not be who they claim to be, leading to shocking revelations and decisions driven by sheer survival instincts.