The story unveils the unconventional life of Dr. William Marston, a Harvard psychologist and inventor who, along with his brilliant and assertive wife Elizabeth, is on a quest to develop the lie detector. His fascination with human behavior and Elizabeth's insights lead them to explore the boundaries of societal norms and conventions. The Marstons' intellectual journey intersects with Olive Byrne, a young and vulnerable student who becomes their research assistant. Olive's presence in the couple's life is not just professional; a deep and complex relationship forms among the three individuals, challenging the era’s rigid morality and brimming with intellectual, emotional, and sexual discoveries.

As the trio navigates the intricacies of their polyamorous bond, their research and personal experiences culminate in the creation of an iconic female superhero. This character is conceived as a symbol of the feminist ideals that the Marstons and Olive cherish: strength, independence, and empowerment. The superhero's philosophy and attributes are heavily influenced by elements of their lives and the dynamics of their relationship. However, the emergence of this radical pop culture figure draws scrutiny and controversy, reflecting society's uneasiness with the trio's lifestyle and the progressive notions they advocate through their creation.