Two women, an African American prostitute named Lee Daniels and a white revolutionary named Karen Brent, are incarcerated together in a brutal and corrupt Southeast Asian prison. Sent to a hellish penal colony, they initially clash due to their diverse backgrounds and differing motivations. However, their mutual struggle to survive the oppressive conditions forges an uneasy alliance. Events take a turn when the heroines are shackled together and manage to escape during a surprise attack on their prison transport.

While on the run, they are pursued by both the police and a ruthless bounty hunter, Ruben, who seeks a reward for their capture. Throughout their journey, Lee and Karen must learn to navigate their differences and work in tandem to evade their pursuers. Their initial mistrust evolves into a partnership rooted in necessity as they face various threats from both the natural environment and those hunting them. Uniting their respective street smarts and revolutionary fervor, they strive to achieve freedom against all odds, marking the beginning of an action-packed and tense adventure.