Serial killer Charles Lee Ray, now trapped inside the doll known as Chucky, is resurrected by his former lover and accomplice, Tiffany. After acquiring Chucky's remains in a police evidence locker, Tiffany performs a voodoo ritual to bring him back to life, but her joy is short-lived. Chucky, driven by the same murderous instincts, kills Tiffany and transfers her soul into a bridal doll as a twisted revenge for her betrayal. Bound by their new doll forms, Chucky and Tiffany embark on a quest to retrieve an amulet that was buried with Ray's human body, which holds the key to returning them both to human form.

As their murderous journey unfolds, the duo manipulates a young couple, Jesse and Jade, who are eloping. Unaware of the dolls' true nature, Jesse and Jade become unwitting accomplices as they travel with what they believe are innocent-looking dolls. A series of violent events and peculiar deaths begin to unravel around them, drawing the attention of the police and placing the couple in the crosshairs of suspicion. As they continue their road trip, the relationship between Jesse and Jade is put to the test while Chucky and Tiffany wreak havoc and leave a bloody trail in their path.