Set in 1958, Richard and Mildred, an interracial couple residing in Virginia, find themselves at the center of a legal battle when they get married. Virginia's anti-miscegenation laws result in their arrest and imprisonment, forcing them to leave the state. They move to Washington D.C. to avoid prosecution, but deeply miss their family and roots back in Virginia.

Yearning to return home, the couple decides to challenge the unjust law. They find support from the American Civil Liberties Union, which takes their case to court. The case eventually reaches the U.S. Supreme Court, symbolizing a monumental fight for civil rights and love against racial discrimination.