In a remote desert town in Arizona, mysterious deaths related to deformities attract the attention of Dr. Matt Hastings, the local physician. Working alongside the county sheriff, they discover that the abnormalities could be linked to the work of Professor Gerald Deemer, a reclusive scientist who has been conducting experiments in his isolated mansion. Dr. Deemer is developing a nutrient designed to combat world hunger by accelerating the growth of animals, but in a tragic turn of events, one of his subjects—a tarantula—escapes and begins to grow at an alarming rate. The spider, now reaching monstrous proportions, becomes a threat to the townspeople as it ravages the desert landscape.

With the terror spreading, Dr. Hastings teams up with Stephanie Clayton, Deemer’s assistant, to find a solution before the creature can cause more devastation. Their investigation reveals more about Deemer's ambitious but perilous experiments and the true extent of the danger posed by the abnormally enlarged spider. As they race against time, tensions mount, leading to desperate measures to confront and neutralize this unnatural predator. Amidst mounting chaos, Hastings and Clayton's resolve is put to the ultimate test as they seek to protect their town from a rapidly escalating menace.