A mysterious and unsettling series of events unfold when a young detective is tasked with the investigation of a bizarre murder. The victim, a beautiful schoolgirl named Tomie, was found decapitated, yet all evidence suggests her head later regenerated. Meanwhile, a high school friend of the victim, Tsukiko, begins experiencing unsettling visions and lapses in her memory following the incident. She becomes increasingly fixated on her late friend and struggles to decipher her own involvement in the puzzling circumstances surrounding Tomie's death. Tsukiko's interactions are further complicated by the reappearance of people claiming to have known Tomie, each recounting a similarly tragic tale about her influence and presence. These stories reveal a haunting pattern, suggesting an extraordinary connection between Tomie and those who become infatuated with her.

As the investigation delves deeper, more individuals are inexplicably drawn into Tomie's ethereal allure, leading to even more inexplicable phenomena. The detective uncovers an underlying theme of obsession and madness among those who encountered the enigmatic girl. Tensions escalate, and Tsukiko's sanity is pushed to the brink as she grapples with increasingly surreal and terrifying experiences. Distorted truths and the paranormal intertwine, painting a picture that is both mesmerizing and macabre. The film teeters on the edge of reality, blurring the lines between life and death and casting doubt over the essence of identity and mortality, as the characters are engulfed in Tomie's eerie legacy.