In a future where mutants are nearly extinct and an aged Logan suffers from the poisoning effects of his own adamantium-laced skeleton, he ekes out a living as a limo driver near the Mexican border. His healing factor has diminished, leaving him in chronic pain and diminished health. Logan cares for Professor Charles Xavier, who is afflicted with a neurodegenerative disease that causes him to lose control of his telepathic abilities, resulting in dangerous seizures. Hidden in an abandoned smelting plant, they, along with the albino mutant Caliban, remain in hiding from the world. However, Logan's attempt at seclusion is disrupted when he encounters a young girl named Laura, who possesses extraordinary fighting abilities eerily similar to his own.

Pursued by dark forces led by a man named Donald Pierce, who works for a powerful corporation, Logan discovers that Laura is a mutant, created from his own DNA, making her effectively his daughter. As Pierce and his cybernetically-enhanced enforcers, the Reavers, seek to capture Laura for their own sinister purposes, Logan is reluctantly drawn back into action. Despite his deteriorating health, he must protect Laura, who continues to display a fierce will and a penchant for violence. Together with Professor Xavier, they embark on a perilous journey, aiming to reach a supposed safe haven for mutants. Along the way, they must confront not only their pursuers but also the haunting consequences of their own pasts.