Bob Munro, a harried executive, is feeling the pressure from his demanding job and distant family. Hoping to reconnect with his wife Jamie, teenage daughter Cassie, and young son Carl, he ditches their planned Hawaiian vacation for a cross-country road trip in a rented RV. Bob's plan is to attend a significant work meeting in Colorado under the pretense of a family bonding experience. The Munros, unfamiliar with the nuances of "RV life," face a series of comedic misadventures as they navigate the open road amidst family tension and Bob's secret agenda.

As they journey, they encounter various oddball characters, including the overly friendly Gornicke family who seem to pop up everywhere the Munros go. As mishaps pile up, Bob struggles to keep his dual set of priorities in balance, leading to a series of chaotic but often heartwarming moments. Despite the dysfunction, the Munros gradually start to come together, discovering the value of family in the process. This sets the stage for a heartfelt culmination that underscores the importance of being present for one another.