During World War II, the 332nd Fighter Group, a squadron composed entirely of African-American pilots known as the Tuskegee Airmen, faces discrimination within the segregated United States Army Air Forces. Despite their proven skills and dedication, they are relegated to second-rate aircraft and non-combat missions. Led by Colonel A.J. Bullard and Major Emanuelle Stance, these pilots are determined to prove their worth. The squadron impresses command with their performance, and they begin to receive more dangerous and crucial missions. Amidst the battles in the skies over Europe, they face not only the enemy but also prejudice from their fellow servicemen.

The Tuskegee Airmen's valor and tenacity gradually earn them respect and more critical assignments, such as escorting bombers deep into enemy territory. They encounter personal challenges and losses that test their resolve and camaraderie. As they integrate into more significant roles within the military, their success starts changing perceptions about race and capability within the armed forces. The film portrays individual stories of bravery, friendship, and the ongoing struggle for equality, encapsulating a significant moment in history when a group of marginalized individuals rose to demonstrate extraordinary heroism and skill against both enemy combatants and systemic racism.