Brigitte and Ginger Fitzgerald are teenage sisters who have a fascination with death, often staging elaborate scenes depicting their own demise. They struggle to fit in at their high school, where they are frequently bullied. One night, Ginger is attacked by a creature and is seriously injured. As the wounds start to heal at an unnatural rate, Ginger begins to undergo dramatic physical and behavioral changes, becoming more aggressive and sexually charged, alarming her younger sister Brigitte.

Brigitte turns to local drug dealer Sam for help after discovering that Ginger's transformation is tied to the werewolf attack. They attempt various remedies to halt the changes, but Ginger's condition worsens. The narrative delves into themes of puberty, sisterhood, and the horror of losing one's humanity. As tensions rise, Brigitte must confront a terrifying reality and make difficult decisions to save both her sister and herself from the impending danger.