In a picturesque seaside town in Connecticut, three young women - Daisy, Kat, and Jojo - work at a local pizza parlor owned by the wise and motherly Leona. Daisy, the fiery and free-spirited one, is consistently on the lookout for a way to escape the confines of small-town life. She becomes romantically involved with Charles, a wealthy and charming prep school dropout, but their differing backgrounds pose a challenge to their budding relationship. Kat, Daisy's studious and responsible younger sister, juggles her job at the pizzeria with her role as a babysitter for Tim, an unhappily married architect. Meanwhile, Jojo, the assertive and quirky member of the trio, grapples with her fear of commitment despite her deep love for her devoted boyfriend, Bill, who wants to get married as soon as possible.

As the girls navigate the complexities of their relationships and personal growth, they each face pivotal moments that test their dreams and the strength of their friendship. The tight-knit community and the familial atmosphere of the Mystic Pizza parlor serve as a backdrop for their individual journeys, offering both solace and wisdom. The interactions with the town's eclectic residents and visitors provide further insight into the challenges they must overcome. Through laughter, heartache, and unexpected revelations, the young women discover more about themselves and the true meaning of love and loyalty.