At the site of the original Jurassic Park on Isla Nublar, a new theme park called Jurassic World has been built upon the ideas of John Hammond. The park is fully operational and filled with genetically engineered dinosaurs exhibited to the amusement of tourists from around the world. Despite the attraction of real-life dinosaurs, the park’s management team is under pressure to continually excite the public and maintain profitability. To boost visitor numbers, the park's geneticists, led by Dr. Henry Wu, create a new hybrid dinosaur, the Indominus rex, which is bigger and more intelligent than any dinosaur known before. However, in their quest to awe guests with new thrills, the park operators underestimate the creature's abilities.

Claire Dearing, the park's operations manager, is busy preparing for the launch of the new attraction when her nephews, Zach and Gray, arrive for a visit to the park. In the meantime, Owen Grady, a former military member and a Velociraptor trainer, conducts behavioral research on the intelligent predators. He develops a rapport with them, asserting dominance yet displaying a mutual respect. When the Indominus rex manages to escape its paddock due to its unforeseen capabilities, the park plunges into chaos. Owen and Claire are thrown together in a desperate effort to track down the vicious and cunning creature that now roams free, threatening the lives of thousands of visitors, including her nephews.