After a devastating car accident that leaves her legs paralyzed, a young woman named Jessabelle returns to her childhood home in Louisiana to recuperate. Moving in with her estranged father, she expects a period of healing and adjustment. Instead, she finds herself faced with a chilling discovery in her old room: a series of videotapes left by her mother, who died of cancer shortly after giving birth to her. The tapes, intended as a gift for her grown-up daughter, are filled with messages and tarot readings that soon take a dark turn, hinting at secrets deeply buried in her family's past.

As Jessabelle delves deeper into her mother's predictions and tries to make sense of the eerie messages, she starts experiencing terrifying visions. The bayou home, surrounded by the murky waters and whispering winds of the swamps, becomes a haunting backdrop for the nightmares that seem to be creeping into reality. She realizes that these supernatural occurrences might be tied to a vengeful spirit seeking to settle scores long overdue. With the help of a childhood friend, Jessabelle must unravel the mysteries of her family's history and confront the ghosts of her past before they consume her future.