Roy Cady is a hitman in New Orleans whose life is upturned when he discovers he has lung cancer. Despite his ailment, Roy's mobster boss tasks him with another job. When the hit goes fatally wrong, Roy finds himself escaping with unexpected baggage—a young prostitute named Raquel "Rocky" Arceneaux. Rocky has been a captive of the local crime boss, and in the chaos, Roy instinctively frees her, finding that she's absconded with some crucial evidence that further endangers them both. During their escape, Roy also finds that Rocky has brought along her 3-year-old sister Tiffany.

As Roy and Rocky are on the run from the crime syndicate, they form an uneasy alliance. Roy, grappling with his terminal diagnosis, sees a path to redemption in protecting Rocky and her sister. The trio embarks on a journey to Galveston, Texas, in an effort to find sanctuary. Amidst their flight, secrets come to light as they learn more about each other's pasts, and their bond deepens. The looming threat of the gangsters in pursuit casts a shadow over their tentative plans, forcing them to confront the reality of their situation and the potential cost of their freedom.