Siblings Ellie and Jimmy are driving home one evening when they get into a car accident on Mulholland Drive. During the chaos, they witness a horrifying attack by a creature that mauls another driver. Both siblings are scratched by the beast, setting off a chain of strange occurrences. As Ellie tries to balance her demanding job as a late-night TV show producer, she grapples with odd new physical abilities and an increasing sense that something is wrong. Meanwhile, Jimmy faces challenges at his high school with bullies and unrequited love, but suddenly finds himself growing stronger and more assertive.

As the full moon looms near, Ellie and Jimmy come to realize they've been afflicted by a werewolf curse. They dig into local folklore and enlist the help of a fortune teller who warns them about their impending transformation unless they can trace their bloodline back to the original werewolf that bit them. As the hunt for the creature intensifies, they encounter others who have fallen victim to its curse. Each discovery propels them closer to uncovering a world where monster legends are terrifyingly real. Facing both external threats and their own inner turmoil, Ellie and Jimmy must act quickly to rid themselves of the curse before it's too late, while unraveling a mystery that reaches far deeper than they initially imagined.