Perdita Durango, a fierce woman with a taste for danger, crosses paths with Romeo Dolorosa, a charismatic criminal with a penchant for Santeria and a reputation that precedes him. Drawn together by a mutual attraction to the dark and forbidden, the two embark on a wild journey fueled by their shared lust for chaos and violence. Their escapades are marked by a trail of reckless abandon as they engage in various criminal activities, all while developing an intense and tumultuous relationship. Their penchant for trouble is matched only by their magnetic pull towards each other, creating an unpredictable and volatile bond that thrives on the edge of society's norms.

The duo concocts a plan to kidnap a young couple—Duane and Estelle—with the intention of using them for a dark and twisted purpose. They aim to deliver their captives as a human sacrifice for a Mexican crime lord, fulfilling a promise to participate in a ritualistic ceremony that flaunts their defiance of conventional morality. As they travel across the desolate landscapes of the U.S.-Mexico border, their path becomes increasingly perilous, drawing the attention of law enforcement. With both the authorities and rival criminals closing in, the couple must navigate a series of confrontations that test the limits of their relationship and their willingness to descend further into their own depravity.