In modern-day New York City, two female vampires, Goody and Stacy, enjoy an immortal life filled with clubbing, fashion, and fun. They sustain themselves on a diet of rodents to avoid taking human lives. Goody, who was turned in the late 1800s, keeps her age a secret from Stacy, who was turned in the 1990s. The two navigate the complexities of eternal life, friendships, and romantic entanglements while managing to keep their true nature hidden. They attend a vampire support group led by Vlad, who helps them adjust to modern society.

Their world is thrown into upheaval when Stacy falls for Joey, a human who happens to be the son of a notorious vampire hunter. Meanwhile, Goody encounters an ex-lover from her past, making her question her eternal youth and the life she has chosen. As both women grapple with their feelings and the dangers that come with them, they are faced with a series of events that force them to confront the reality of their existence and what it means to live forever.