After a narrow escape from her burning home, Laurie Strode is rushed to the hospital with life-threatening injuries, believing she has finally killed Michael Myers, the masked figure who has haunted her since she survived his Halloween night killing spree in 1978. Unbeknownst to Laurie, Michael emerges from the inferno, his murderous rage undiminished. Rampaging through Haddonfield, Michael leaves a trail of bloodshed, his brutal violence becoming more wanton and horrific with each victim.

As news of Michael's survival and the ensuing carnage spreads, the town is engulfed in terror. A vigilante group spearheaded by Tommy Doyle, one of Michael's previous victims, forms to protect the community and end Michael’s reign of terror. Laurie's daughter, Karen, and granddaughter, Allyson, struggle with the decision to flee or join the townsfolk in their fight. The town's rage and thirst for vengeance grow as they hunt Michael, with survivors of his past atrocities coming together to confront the unstoppable force that has tormented them for decades.