Twelve strangers wake up in a clearing, unsure of how they arrived or why they're there. They discover a large box full of weaponry, and as they arm themselves, they soon realize they are being hunted for sport. The hunters, a group of elite individuals, have gathered these "deplorables" from across the nation, based on their online behavior and controversial views. As the hunted grapple with their situation, they must navigate a deadly game in which the hunters have seemingly stacked all odds in their favor.

Among the prey is Crystal, a woman from Mississippi with a mysterious past and a surprising set of combat skills. While the others are picked off through a series of orchestrated traps and attacks, Crystal emerges as the most adept at evading and combating their attackers. She uses her intelligence and resourcefulness to unravel the mystery of why they have been chosen for this twisted game. As tensions escalate and true intentions come to light, Crystal seeks to turn the tables on their affluent pursuers.