Bella, a rescue dog, is raised by a young medical student named Lucas and his mother in Denver, Colorado. Bella's joyful life with Lucas is abruptly interrupted when she is picked up by animal control due to breed-specific legislation that bans pit bulls in the city. Fearing for Bella's safety, Lucas arranges for her to stay with friends outside the city limits while he works to change the law and bring her home. Unfortunately, Bella becomes confused and, driven by her strong attachment to Lucas, escapes the temporary home to embark on a journey back to Denver.

As Bella navigates through the vast wilderness and urban areas, she encounters various animals and befriends a young cougar cub, demonstrating her resilience and loyalty. Throughout her journey, she also crosses paths with different people who influence her adventure and growth in significant ways. The journey is fraught with challenges that test Bella’s survival skills and determination, but her unwavering love for Lucas propels her forward. This epic quest highlights the themes of love, perseverance, and the unbreakable bond between a pet and its owner.