In a post-apocalyptic world ravaged by a catastrophic drought, Earth is controlled by the tyrannical Water & Power corporation, which monopolizes the planet's water supply. Amidst this desolation lives Rebecca, a fiercely independent and rebellious young woman who survives by raiding Water & Power's resources and challenging their oppressive control. When Water & Power's forces, led by the ruthless Kesslee, murder her boyfriend and capture her, Rebecca is taken to their fortress to be made an example of. Undeterred, she manages to escape and commandeer a highly advanced tank, thus emerging with a new identity and purpose.

After her daring escape, Rebecca joins forces with Jet, a brilliant but timid mechanic, and a band of mutated kangaroo-human hybrids known as the Rippers. Together, they form an unconventional team that seeks to overthrow Water & Power’s brutal reign. As their audacious plans unfold, Rebecca, now fully embraced as Tank Girl, faces numerous battles and obstacles while honing her skills and strengthening her resolve. Despite the overwhelming odds, she becomes an iconic symbol of resistance in the fight for freedom and water in the arid wasteland.