An American nurse named Karen living in Tokyo is exposed to a mysterious supernatural curse, one that locks a person in a powerful rage before claiming their life and spreading to another victim. The curse originates from a house where a terrible event occurred, and now, anyone who steps inside this home finds themselves gripped by fear and tormented by disturbing visions. Karen encounters this curse when she substitutes for another nurse who failed to show up at work and finds herself within the haunted abode.

After experiencing these terrifying episodes, Karen is driven to uncover the secrets of the house. She learns that the curse was born when a jealous rage led to a family's violent demise, thus creating a pattern of horror that repeats itself. As Karen tries to stop the cycle of anger, it becomes clear that the grudge won't let go easily, ensnaring its victims into a never-ending spiral of fear and madness. Without knowing, Karen must find a way to break free from the curse's grasp before it consumes her as well.