In a world ravaged by a virus that turns its victims into the Undead, Alice continues her journey to find survivors and lead them to safety. Her battle with the Umbrella Corporation escalates as she seeks revenge for the experimental biogenetic alterations they’ve performed on her, granting her superhuman abilities. Alice receives a message from a safe haven called Arcadia, promising food, shelter, and safety. As she scans the globe for survivors to rescue, she heads to Los Angeles where she meets a small group of survivors holed up in a prison, surrounded by masses of the infected.

Within the prison stronghold, Alice encounters new allies including a former basketball star and an enigmatic stranger who may hold the key to their escape. Trust among the survivors is fragile and the situation is dire, with the hordes outside and the promise of a safe haven tantalizingly out of reach. As they make plans to reach Arcadia, they must first find a way to break out of their fortified sanctuary, knowing that the city swarms with the Undead, and that Umbrella forces are never far behind, continuing their relentless pursuit of Alice and the remnants of humanity.