After defeating international terrorist Owen Shaw and securing amnesty for their past crimes, the crew has returned to the United States to live normal lives. However, Owen's older brother, Deckard Shaw, is out for revenge. A rogue special forces assassin, Deckard starts his campaign of vengeance by critically injuring the crew's leader, Dominic Toretto's close friend and DSS agent, Luke Hobbs, in a surprise attack. He then aims to take down the rest of the crew one by one. The first on his list is long-time team member Han, which connects back to an event the crew thought was long past. With the threat of Deckard looming over their heads, the crew must once again band together to protect their family and stop this new adversary.

In the midst of these troubles, the crew is approached by a shadowy government operative known as Mr. Nobody, who offers them a way to find Deckard through the use of a revolutionary tracking device called the God's Eye. In exchange, they must first rescue the device's creator, a hacker named Ramsey, from a terrorist known as Mose Jakande, who has captured her. With the promise of this technology to help them in their quest, Dominic and his team set off on a series of high-octane missions across the globe to save Ramsey and secure the God's Eye, all while staying one step ahead of Deckard Shaw's relentless pursuit.