In 1940s World War II-era America, scrawny but spirited Steve Rogers is determined to serve his country despite being repeatedly rejected for military service due to various health and physical issues. Upon discovering Steve's unwavering desire to contribute and his inherent goodness, Dr. Abraham Erskine enlists him for a secret project: the creation of a super-soldier. Rogers undergoes an experimental procedure that successfully transforms him into a powerful warrior with enhanced strength, agility, and endurance. Dubbed Captain America, he initially serves as a symbol to boost morale on the home front, touring the nation and promoting war bonds.

As the war intensifies, Captain America's role shifts from mere propaganda tool to active combatant. He joins forces with British agent Peggy Carter and his friend Bucky Barnes to form a select team aimed at taking down HYDRA, the Nazi's advanced weapons division led by the ruthless Johann Schmidt. Schmidt, also known as the Red Skull, has obtained a mysterious artifact with untold powers, intending to use it to turn the tide of the war in favor of the Axis powers. As Captain America and his team delve deeper into enemy territory, they encounter technological marvels, face harrowing battles, and uncover the full extent of HYDRA's plans for global domination.