Four young outsiders acquire extraordinary abilities after a teleportation experiment goes awry. Reed Richards, a brilliant but overlooked scientist, has long been obsessed with building a teleportation device to access alternate dimensions. Together with his childhood friend Ben Grimm, Reed is recruited by Dr. Franklin Storm to join his own prodigy daughter, Sue, and hot-headed son, Johnny, at the Baxter Foundation. The team strives to complete "Quantum Gate," a project initiated by Storm and his protégé, Victor Von Doom. Fueled by dreams of discovery, the ambitious group embarks on an unsanctioned trial to finally realize their years of research and theories.

However, their voyage takes an unexpected turn when something goes wrong, and the crew finds themselves exposed to otherworldly energy in the alternate dimension. The catastrophic incident imbues them with incredible powers—Reed gains the ability to stretch his body; Sue develops the power to become invisible and create force fields; Johnny can engulf his body in flames and fly; and Ben transforms into a super-strong, rocky creature. As they come to terms with their altered states, the group struggles to harness their new abilities while dealing with personal conflicts and the repercussions of their unauthorized trip. Meanwhile, their changes spur the attention of the government, leading to unforeseen challenges as they seek to mend the fractured bonds amongst each other.