A group of five friends from college reunite after ten years for a wild bachelorette weekend in Miami. The central figure is Jess, a woman striving for political success, who is about to marry her fiancé Peter. Alongside Jess is her best friend Alice, the overbearing and emotional teacher; Frankie, an activist with a history of run-ins with the law; Blair, a wealthy real estate agent going through a divorce and custody battle; and Pippa, Jess's friend from her semester abroad in Australia. The women are looking forward to a weekend full of partying and rekindling their close bonds.

The celebration takes a dark turn when, in the heat of their revelry, they accidentally kill a male stripper who had been hired for the evening. Panicked and unsure of what to do, the friends grapple with the gravity of the situation. As they try to figure out how to handle the death, their differing personalities and the strain of the incident bring deep-seated issues and hidden resentments to the surface. The night spirals out of control, entangling the women in a series of outrageous events as they attempt to cover up the accident and maintain their innocence.