Bruce Banner is a scientist who, due to exposure to gamma radiation, has transformed into the Hulk, a creature of immense strength but with little control over his rage. Haunted by this condition and pursued by the military, Banner is on the run, desperate to find a cure that will allow him to live a normal life and be with the woman he loves, Betty Ross. He travels the globe evading General Thaddeus "Thunderbolt" Ross, Betty’s father, who sees the Hulk not as a human to be saved but as a weapon to be captured and controlled. Banner's only hope lies with his own research and the chance of reversing the transformation, but time and resources are running out.

The military, meanwhile, employs the skillful soldier Emil Blonsky to capture Banner. Eager to harness the Hulk's power, Blonsky undergoes a procedure to enhance his physical abilities, putting him on a collision course with Banner's alter ego. As Blonsky’s obsession with power grows, Banner struggles to evade capture while searching for a cure, reconnecting with Betty, who remains his emotional anchor. In the shadows, a new threat begins to emerge, one that challenges Banner's resolve and threatens to unleash a greater danger upon the world. The chase leads to a confrontation that tests the limits of Banner’s ability to contain the raging spirit within him.