In Manhattan, a group of friends gather to throw a surprise farewell party for Rob, who is leaving New York to pursue a career opportunity in Japan. The night is documented through the lens of a video camera held by Rob's friend, Hud, who interviews guests and captures the celebration. As the party progresses, flirtations and past romantic tensions surface, particularly between Rob and his close friend Beth, with whom he has unresolved feelings. The festivities are abruptly interrupted when a sudden and violent tremor shakes the city, cutting off electricity and spawning a sense of immediate panic among the partygoers and residents alike.

The group turns on the news just in time to see reports of an unidentified disaster in the city. Deciding to evacuate, they make their way through the streets, only to be met with chaos and destruction. Witnessing explosions and the decimation of landmarks, they come to realize that New York is under attack by an enormous creature. As they struggle to survive and make sense of the situation, they continue to document their harrowing experience, capturing the terror and confusion that grips the city. Amidst the chaos, Rob is determined to rescue Beth, who is trapped in her apartment, and the group sets off on a perilous journey through the crumbling city, all while being hunted by smaller creatures that have begun to infest the streets.