Dominic "Dom" Toretto and Letty Ortiz are on their honeymoon in Havana when Dom's peaceful life is shattered by the mysterious cyberterrorist Cipher. She forces Dom into working for her by showing him an unknown form of leverage, leaving him no choice but to betray his team during a mission. The team is left in shock as Dom goes rogue, aiding Cipher in her plot to trigger a world-shaking event involving nuclear weaponry. Under Cipher's command, Dom leads a theft of an EMP device, which further solidifies his betrayal. The team, feeling betrayed and bewildered by Dom's actions, struggle to cope with their leader's sudden turn to the dark side.

Hobbs is framed in Dom's scheme and sent to the same high-security prison where Deckard Shaw is held. After a chaotic breakout facilitated by Mr. Nobody and his protégé, they both join Dom's crew on the condition that they bring Dom back. The team crosses paths with Dom in various global locations, engaging in high-stakes chases and battles, but they are consistently outmaneuvered by Cipher's superior tactics and Dom's unparalleled driving skills. Meanwhile, the team discovers a trail of clues pointing to the reason behind Dom's betrayal and scramble to find a way to reach out to him, hoping to bring him back to the fold before Cipher can enact her final plan.